Gryffin's Tail has moved!

Gryffin's Tail has a new home. It got too hard to mirror to this site. I don't maintain this site anymore.

Subscribe via email will subscribe you to the new site feed. Below is an RSS feed of the new site.

To all my email followers, I've transferred the Feedburner address to the new site so you should start receiving emails again. I didn't know this page stopped mirroring until a day or so ago. I'm sorry you've missed out for the last few months but the good news is that I don't post much so it'll be easy to catch up!



RSS feed of the new Gryffin's Tail site



Subscribe via email to the new site

Enter your email address:

Delivered by FeedBurner






Wednesday, July 8, 2009

T helper cell type 1 (Th1)- and Th2-like responses are present in mice with gastric candidiasis but protective immunity is associated with Th1 develop

So why do antivirals cause yeast? Here's a study that helps explain the TH1/TH2 roles. I think I have a few more that I'll dig up and post in the next few days.

J Infect Dis. 1995 May;171(5):1279-88.

Cenci E, Mencacci A, Spaccapelo R, Tonnetti L, Mosci P, Enssle KH, Puccetti P, Romani L, Bistoni F.

Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy.

The relative contributions of local T helper cell type 1 (Th1)- and Th2-like responses to the course of primary and secondary gastrointestinal (GI) candidiasis were examined in adult immunocompetent BALB/c mice. Both Th1 cytokines, such as interferon-gamma (IFN-gamma), and the Th2 cytokines, interleukin (IL)-4 and IL-5, were produced by CD4+ cells from Peyer's patches (PP) and mesenteric lymph nodes at a time when the fungus was cleared from the stomach and intestine. Augmentation of antigen-specific Th2-like responses by treatment with cholera toxin did not modify the course of disease. In contrast, treatment with soluble IL-4 receptor, which increased Th1 cells, was associated with enhanced yeast clearance. In addition, IFN-gamma but not IL-4 mRNA was present in PP and spleen CD4+ cells in mice resistant to subsequent GI inoculation. Activation of Th1- but not Th2-like responses may be responsible locally for controlling GI candidiasis and generating protective immunity.

PMID: 7751704 [PubMed - indexed for MEDLINE]

Gryffin's Tail © 2010

Blogger Templates by Splashy Templates