Gryffin's Tail has moved!

Gryffin's Tail has a new home. It got too hard to mirror to this site. I don't maintain this site anymore.

Subscribe via email will subscribe you to the new site feed. Below is an RSS feed of the new site.

To all my email followers, I've transferred the Feedburner address to the new site so you should start receiving emails again. I didn't know this page stopped mirroring until a day or so ago. I'm sorry you've missed out for the last few months but the good news is that I don't post much so it'll be easy to catch up!

*

*

RSS feed of the new Gryffin's Tail site

*

*

Subscribe via email to the new site

Enter your email address:

Delivered by FeedBurner

*

*

Tweets!

*

*

Tuesday, July 7, 2009

New Study Pinpoints Difference in the Way Children with Autism Learn New Behaviors



Newswise — Researchers from the Kennedy Krieger Institute and Johns Hopkins University School of Medicine have collaborated to uncover important new insights into the neurological basis of autism. Their new study, published in the journal Nature Neuroscience, examined patterns of movement as children with autism and typically developing children learned to control a novel tool. The findings suggest that children with autism appear to learn new actions differently than do typically developing children. As compared to their typically developing peers, children with autism relied much more on their own internal sense of body position (proprioception), rather than visual information coming from the external world to learn new patterns of movement. Furthermore, researchers found that the greater the reliance on proprioception, the greater the child’s impairment in social skills, motor skills and imitation.

Previous research has shown that children with autism have difficulty with motor skills, which appears to be associated with abnormalities in how the brain learns motor actions. To study the models formed in the brain when children with autism learn a new movement, researchers measured patterns of generalization as 14 children with autism and 13 typically developing children learned to reach using a novel tool. They then examined how well children were able to generalize what they learned in two separate ways – one that detected how much they relied on visual information to guide learning and one that detected how much they relied on proprioceptive information to guide learning.

“These findings can lead to important advances in methods for treating autism. Applying the knowledge gained in the current study, targeted interventions can be developed that enhance visuo-motor associations in children with autism as they learn new skills,” said Dr. Stewart H. Mostofsky, study author and a pediatric neurologist in the Department of Developmental Cognitive Neurology at the Kennedy Krieger Institute. “If done early enough, this could help to improve development of motor, social and communicative skills in children with autism. Further, it could also improve their ability to understand social cues because the brain systems critical to forming internal models of behavior that guide our actions are also critical to developing an understanding of the meaning of those actions.”

The study findings also provide support for observations from previous studies suggesting that autism may be associated with abnormalities in the wiring of the brain; specifically, with overdevelopment of short range white matter connections between neighboring brain regions and underdevelopment of longer distance connections between distant brain regions. The findings from this study are consistent with this pattern of abnormal connectivity, as the brain regions involved in proprioception are closely linked to motor areas, while visual-motor processing depends on more distant connections.

“These findings not only demonstrate why children with autism have difficulty learning motor skills, but also provide real insight into why these children have difficulty learning to interact with the world around them,” said Dr. Reza Shadmehr, senior study author and Professor of Biomedical Engineering and Neuroscience at the John Hopkins University School of Medicine. “If the way their brain is wired is not allowing them to rely as much as typically developing children on external visual cues to guide behavior, they may have difficulty learning how to interact with other people and interpret the nature of other people’s actions.”

Potential next steps include the use of neuroimaging to investigate whether or not proprioceptive versus visual feedback is actually associated with abnormal patterns of structural and functional connectivity in the brain of children with autism. Additionally, researchers may study if patterns of motor learning can be altered to increase visual connections in specific regions of the brain. Through interventions such as cortical stimulation, biofeedback and behavioral approaches, researchers are looking to investigate if there is an improvement in children with autism’s ability to rely on visual input to guide how they learn a range of behavioral skills.

About the Kennedy Krieger Institute
Internationally recognized for improving the lives of children and adolescents with disorders and injuries of the brain and spinal cord, the Kennedy Krieger Institute in Baltimore, MD serves more than 13,000 individuals each year through inpatient and outpatient clinics, home and community services and school-based programs. Kennedy Krieger provides a wide range of services for children with developmental concerns mild to severe, and is home to a team of investigators who are contributing to the understanding of how disorders develop while pioneering new interventions and earlier diagnosis. For more information on Kennedy Krieger Institute, visit www.kennedykrieger.org.

About the basic sciences at the Johns Hopkins University School of Medicine
The mission of the Institute for Basic Biomedical Sciences at the Johns Hopkins School of Medicine is to promote the fundamental research that drives advances in medicine. By fostering a unique and collaborative environment that bridges basic science and clinical research, the IBBS supports and encourages interdisciplinary interactions that lead to discovery and innovation and educates and trains future leaders in biomedical research.
 

Gryffin's Tail © 2010

Blogger Templates by Splashy Templates